Clinically tested against retinol and backed by by 5 independent trial

7.2X BETTER WRINKLE REDUCTION VS RETINOL.

Figure 1. Images of periorbital wrinkle following 8 weeks consecutive application of the REGENEX^TM Renewal Serum.

Figure 2. Changes in average overall wrinkle size following 8 consecutive weeks application of REGENEX^TM and Retinol.

Study overview:

Comparing the efficacies of Modern Molecules REGENEX ^TM Renewal Serum and Retinol for reducing the appearance of wrinkles.

Subjects:
21 male and female subjects aged 49 to 60 years old with varying signs of facial ageing.

Methodology:
Randomised and placebo-controlled study with 1:1 ratio of participants applying on opposite sides of the face: on one half of the face Modern Molecules REGENEX ^TM Renewal Serum against placebo base cream with Retinol on the other half. Applied daily over 8 weeks.

Assessments conducted at 0, 2, 4, 6, and 8 weeks at 5 wrinkles sites (glabellar, nasolabial folds, upper lip, periorbital, forehead) for overall size, depth, width and maximum depth via 3D imaging.

Test Centre:
Dermapro Skin Research Institute.
Seoul, Republic of Korea
June, 2024 - August, 2024

Clinical Results:

(1) Glabellar (Between Brows) Average Overall Wrinkle Size Reduction

REGENEX^TM: - 10.4%
Retinol: - 5.7%

(2) Nasolabial (Side of Nose to Mouth) Folds Average Overall Wrinkle Size Reduction

REGENEX^TM: - 8.9%
Retinol: - 3.6%

(3) Upper Lip Average Overall Wrinkle Size Reduction

REGENEX^TM : - 6.2%
Retinol: - 3.31%

(4) Periorbital (Around Eyes) Wrinkle Average Overall Wrinkle Size Reduction

REGENEX^TM - 8.2%
Retinol: - 5.5%

(5) Forehead Wrinkle Average Overall Wrinkle Size Reduction

REGENEX^TM: - 9.5%
Retinol: - 1.2%

Key Observation:

In 4 weeks: 7.2x better anti-ageing results than Retinol for forehead wrinkles.

Study Conclusion:
Modern Molecules REGENEX^TM Renewal Serum showed superior efficacy to Retinol for reduction of appearance of wrinkles with a good safety profile. A statistically significant result was achieve with REGENEX^TM Renewal Serum after only 2 weeks, evident across all 5 wrinkle sites. After 8 weeks of treatment, subjects showed an average 11.74% reduction of wrinkle depth and 11.10% reduction of wrinkle size.

17X BETTER ANTI-PIGMENTATION VS RETINOL.

Figure 1. Images of skin colour in hyperpigmentation area following 8 weeks of application of REGENEX^TM Renewal Serum.

Figure 2. Changes in hyperpigmentation following 8 consecutive weeks application of REGENEX^TM and Retinol.

Study overview:
Comparing the efficacies of Modern Molecules REGENEX^TM Serum and Retinol for reducing the appearance of pigmentation and age spots.

Subjects:
21 male and female subjects aged 49 to 60 years old with hyper-pigmentation, age spots, or other uneven tone.

Methodology:
Randomised and placebo-controlled study with 1:1 ratio of participants applying on opposite sides of the face: on one half of the face Modern Molecules REGENEX^TM Renewal Serum against placebo base cream with Retinol on the other half. Applied daily over 8 weeks.
Assessments conducted at 0, 2, 4, 6, and 8 weeks on skin colour in hyperpigmentation measured using a Spectrophotometer.

Test Centre:
Dermapro Skin Research Center.
Seoul, Republic of Korea
June, 2024 - August, 2024

Clinical Results:
Statistical analysis of skin colour in hyperpigmentation area parameter after 8 weeks

REGENEX^TM
L*Value Reduction: - 1.61%

Retinol
L*Value Reduction: - 0.35%

*The L* value correlates with the level of pigmentation of the skin.

Key Observation:
In 2 weeks: 17x more reduction in hyperpigmentation than Retinol

Study Conclusion:
Modern Molecules REGENEX^TM Renewal Serum showed superior efficacy to Retinol for reduction of age spots. A statistically significant result was achieve with REGENEX^TM Renewal Serum after only 2 weeks with 17x more reduction in hyperpigmentation compared to Retinol. After 8 weeks of treatment, subjects showed an average 1.61% reduction of hyperpigmentation.

89% PREFERS REGENEX^TM OVER RETINOL.

Figure 1. Images of subject #1’s skin comparing signs of ageing after 28 days of application of REGENEX^TM Renewal Serum.

Figure 2. Images of subject #2’s skin comparing signs of ageing after 28 days of application of REGENEX^TM Renewal Serum.

Figure 3. Images of subject #3’s skin comparing signs of ageing after 28 days of application of REGENEX^TM Renewal Serum.

Study overview:

User trial to gather consumer perception and capture visual performance of Modern Molecules REGENEX^TM Renewal Serum in reducing the appearance of all signs of ageing including wrinkles, pigmentation, roughness, uneven tone, dullness and lack of firmness in 4 weeks.

Subjects:

20 Female and 5 Male participants aged 30-52 years old with varying early sign of facial ageing.

Methodology:

Qualitative study with photos taken of skin at day 0 and week 4 alongside written feedback forms and testimonials to capture perceived formula benefits. Applied daily over 4 weeks.

Singapore, June 2024.

Clinical Results:

89% agree that REGENEX^TM is better than Retinol.
97% agree that skin looks firmer, lifted and plump.
93% agree that the skin looks more youthful.
97% agree that skin’s tone and texture improved.
73% saw reduction in skin pigmentation.
80% saw visible reduction in fine lines and wrinkles.
93% agree that skin looks and feels smoother.
90% agree that skin looks visibly brighter.

Study Conclusion:
Majority of participants experienced instant improved hydration and plumpness on day 0 with first application. After 4 weeks of using REGENEX^TM Renewal Serum in the evening, over 97% of participants observed improvements in skin firmness, plumpness, texture and skin tone. 93% agree that skin looks more youthful and smooth. 90% observed visibly brighter skin and 89% prefer REGENEX^TM over Retinol for anti-ageing results. Visible and significant reduction in wrinkles and age spots are also captured on camera in-studio with 3 participants.

DELAYS AGEING BY 5.5 YEARS IN 2 MONTHS.

Figure 1. Images of skin comparing per-orbital wrinkles after 8 weeks of application of active ingredient.

Figure 2. Changes in skin tone and wrinkle size following 8 consecutive weeks application of Peptide Complex in REGENEX^TM.

Study overview:

Examining the anti-ageing performance of the branded Peptide Complex active in REGENEX^TM for reducing the appearance of all signs of ageing including wrinkles, roughness and lack of elasticity and tone.

Subjects:

23 female participants with 56 years mean age and varying signs of facial ageing.

Methodology:

Twice daily application of a cream containing branded Peptide Complex active in REGENEX^TM for 2 months on one half of the face against placebo.
Assessments conducted before and after 2 months treatment across ageing parameters including wrinkle surface, density, depth, volume as well as skin roughness, elasticity and tone.

Test Centre:

Sederma, France

December 2012

Clinical Results - In 8 Weeks:

photo-induced ageing delayed by 5½ years
- 39.4% surface with deep wrinkles
- 16.2% skin roughness
+ 15.5% skin tone
- 32.9% wrinkle density
- 19.9% wrinkle depth
- 23.3% wrinkle volume

Study Conclusion:
The anti-wrinkle efficacy has been measured as equivalent to an age gain by 1.8 years in 1 month, and up to 5.5 years in 2 months. Effects on wrinkles and skin quality are significant after 2 months for both men and women with average surface occupied by wrinkles reduced by 39.4%.

+65% IN COLLAGEN PRODUCTION.

Figure 1. Changes in skin tone and wrinkle size following 2 consecutive weeks application of Exosomes in REGENEX^TM.

Study overview:

Examining the anti-ageing performance of the branded Exosome active in REGENEX^TM on skin cell regeneration key indicators such as collagen production, wound healing, skin radiance, moisture, density and elasticity.

Subjects

In-vitro: Human dermal fibroblast cells.
In-vivo: 23 female participants aged 20-60 years old for 2 weeks.

Test Centre:

ABio Materials, Korea

Clinical Results:

In-vitro (test tube) study:

65% increase in collagen production
71.7% increase in wound healing
83% increase in anti-inflammatory effect

In vivo (human volunteers) in 2 weeks:

49.9% increase in skin radiance
47.2% increase in skin moisture
20.1% increase in skin density
5.1% increase in skin elasticity

Study Conclusion:
Exosomes’ regenerative properties were observed via in-vitro study using human dermal fibroblast cells with increased collagen product and accelerated wound healing. On human subjects, Exosomes demonstrated significant improvements on skin radiance, moisture, density and elasticity in 2 weeks.